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All three mutants show reduced maximal oxygen consumption rate, decreased ATP production, and increased ROS in SH-SY5Y cell lines

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A casecontrol study that included 67 PD patients compared to 24 healthy controls showed that plasma levels of -synuclein, NLRP3 inflammasome, caspase-1, and IL-1 were increased in PD patients compared to healthy controls (Fan et al