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Additionally, the glucose-lowering effects of SGLT2is are not dependent on the level of insulin secretion or insulin resistance, making them suitable for patients with T2DM and comorbid conditions such as severe obesity

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By contrast, Sakamoto's group recently provided new supportive elements strengthening the key role of mitochondria-mediated modulation of cellular energy homeostasis in the inhibition of hepatic gluconeogenesis by metformin