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Weight Loss: Comparable to Bariatric Outcomes Tirzepatide has shown an unprecedented effect on body weight among antidiabetic drugs: Average weight loss of 10.515 kg (2333 lbs) in type 2 diabetes patients Even greater results (up to 22.5% body weight reduction) in non-diabetic individuals with obesity, per the SURMOUNT-1 trial This places Tirzepatide in competition with dedicated weight-loss medications and even some bariatric procedures, making it a dual-action solution for metabolic disease
For example, semaglutide 2.4 mg (Wegovy) has been shown to reduce major adverse cardiovascular events in adults with overweight or obesity and established cardiovascular disease, even in the absence of diabetes
Patients who have experienced a serious hypersensitivity reaction should not be rechallenged with tirzepatide unless under the direct supervision of an allergist or immunologist
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