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However, in the presence of various types and levels of stress, p53 can be activated and accumulated to coordinate cellular responses
239 In addition, high concentrations of calcium ions also indirectly down-regulated Mfn1 and Mfn2, further inhibited mitochondrial fusion, that ultimately promoted mitochondrial fission in senescent cells
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Likewise, when analyzing the developmental dynamics in human embryos, we found that they seem to better withstand the maternal to embryonic transition which reaches its peak at D3 of development (Vassena et al., 2011)
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