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Metabolic and vascular contributions to ADRD It is important to recognize that the etiology of ADRD is multifactorial and heterogeneous (Iturria-Medina et al., 2016

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Phytosterols protect against osteoporosis by regulating gut microbiota

4.2.4 Lipid reactive oxygen species (Lipid-ROS) Lipid-ROS are reactive oxygen species produced during lipid peroxidation, and their accumulation is a core feature of ferroptosis

Changes in MtDNA copy number in senescent oocytes The prevalence of infertility, spontaneous abortion, and congenital disabilities has increased in recent years with increasing reproductive age in women, and the core pathologic basis of these reproductive outcomes lies in the decline in developmental potential triggered by damage to the quality of oocytes [46, 47]