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Local side effects: Common local side effects of nasal spray may include temporary nasal irritation or dryness, and occasional nosebleeds with prolonged or excessive use [14]

Both ligands had similar cAMP potency but the exendin-4-C16 showed 2.5-fold bias towards G protein recruitment and a 60% reduction in -arrestin-2 recruitment efficacy compared to exendin-4, as well as reduced GLP-1R endocytosis and preferential targeting towards recycling pathways

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As these medications including semaglutide (Ozempic, Wegovy) and tirzepatide (Mounjaro) continue to make headlines, a more nuanced approach to their administration has evolved: microdosing