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GLP-1 medications are peptide-based compounds with relatively high molecular weight and low lipid solubility

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Treatment with oral semaglutide improves the fasting lipid level profile, as exploratory analysis resulted in a statistically superior reduction in total cholesterol [35, 38, 42], low-density lipoprotein (LDL) [35, 42], triacylglycerols (TAGs) [35, 38, 39], and very-low-density lipoprotein (VLDL) compared to the effects of placebo [38]

Then, the BMECs were collected and washed three times with PBS, and quantitative uptake was tested with a FACS Calibur flow cytometer (BD Biosciences, USA)

Furthermore, neurotoxicity can exacerbate oxidative stress by disrupting mitochondrial metabolism and impairing the activity of antioxidant enzymes, thereby intensifying neurotoxic effects