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4-OHE2 quinones are highly reactive electrophiles that form depurinating DNA adducts covalently bonding to adenine and guanine bases in DNA and triggering their removal from the DNA backbone

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Abstract Recent studies have found that vasogenic brain edema is present during hepatic encephalopathy following acute liver failure and is dependent on increased matrix metalloproteinase 9 (MMP9) activity and downregulation of tight junction proteins

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