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Circulation 145 , 375391 (2022)

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The clinical trial evidence indicates that tirzepatide is associated with better glycemic control and weight reduction than the conventional GLP-1 monotherapy, with the SURPASS clinical trial program being associated with HbA1c changes of up to 2.4% compared to baseline and weight reduction of more than 22% of the baseline weight at the highest dosage

A previous study demonstrated that the circadian transcription factor NFIL3, which controls the expression of circadian-clock genes, may be a crucial molecule in the influence of the gut microbiota on host lipid metabolism and body composition [56]

In order to ensure the reproducibility of the results, it is necessary to control the operation of each step in the experimental process