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Most of the foundational studies are animal models, with a growing body of clinical observation and anecdotal reporting from practitioners and patients

As pointed out [60], it has to be the counteraction of the reduced capillary perfusion pressure, increased cerebral blood volume, venous flow obstruction, increased intracranial pressure and blood-brain barrier disruption, resulting in a decreased cerebral blood flow [60]

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The research pipeline is accelerating

In one revealing study, viral antigen persistence was detected in gut mucosa approximately 7 months after mild COVID-19 infection in 32 of 46 patients, with viral nucleocapsid protein persisting in 24 of 46 patients