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To this end, we synthesized a number of permethylated quinolinium analogues[17] guided by in silico calculation of partition coefficient (clogP).[26] Addition of hydrophobic methyl group substitutions around the quinolinium scaffold (previously shown to negatively impact NNMT inhibitory activity)[17] only slightly improved membrane permeability via passive transport as indicated by the low, but non-zero, permeability values for 1,8-diMQ and 1,2,4,8-tetraMQ (Table 1)

As an illustration, they are involved in processes like stathmin- reliant microtubule reorganization or HistoneH3-mediated chromatin condensation

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