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Safety, Dangers, and Regulatory Considerations TB500 Safety: TB500 has shown promising safety outcomes in preclinical studies, exhibiting minimal toxicity

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Oral troches or tablets or buccal films: Less common but suitable for patients averse to invasive injections

First introduced by Maskin in 2010, who hypothesized that mechanically widening the orifices could provide better relief of symptoms, this method showed immediate improvement of symptoms for 24 out of 25 his patients