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It has undergone multiple validations and generated insights consistent with current findings, suggesting that it can guide experiments on brain aging and diseases, including those on disease-associated genetic variants, enzymatic deficiencies, and the effects of different intervention strategies

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Thus, the pathogenesis of gout is fundamentally driven by hyperuricemia, which serves as both a precursor and a central pathological hub

Changes in GH appear to be consistent, with several studies reporting increased GH levels following surgery (9294), whereas the response of total IGF-I to bariatric surgery is more variable (117)