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While the initial results of clinical trials are promising, the long-term efficacy and sustainability of GLP-1 analogue treatments depend on the adoption of healthy lifestyle changes

While these medications are not primarily classified as hormonal therapies, their metabolic effects inevitably intersect with endocrine function, particularly in patients with obesity and insulin resistanceconditions known to disrupt multiple hormonal axes

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Recent studies have highlighted key molecular targets such as SREBP (Attal et al., 2022), PPAR- (Yue et al., 2021), AMPK (Fang et al., 2022a), MAPK (Huang et al., 2023), Nrf2 (Lu et al., 2016), NF-B (Kong et al., 2021), and SIRT (Ren et al., 2020) as mechanisms by which Chinese botanical drugs regulate lipid metabolism in the liver