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A study evaluating the effectiveness of a 45-day VLEKT in improving acne in 31 young women with moderate acne and grade I obesity showed a reduction in markers of oxidative stress, such as reactive oxygen metabolite derivatives (dROMs), and a decrease in pro-inflammatory metabolites, including trimethylamine N-oxide (TMAO)
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In a mouse model, treatment was shown to limit the rise in syndecan-1, the main marker of endotheliopathy [141], and to help maintain glycocalyx thickness (intravital microscopy) in treated animals with HS
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