A., Lutgens, E., Schomakers, B
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In comparison with asymptomatic volunteers, no association between Modic changes and trauma was found but rather with pre-existing disc degeneration
Furthermore, in a post hoc analysis of the cagrilintide monotherapy arm in REDEFINE 1, cagrilintide led to clinically meaningful reductions in body weight and waist circumference versus placebo and presented a favourable safety profile [11]
Here, we determine structures of cagrilintide bound to Gs-coupled, active, amylin receptors (AMY 1 R, AMY 2 R, AMY 3 R) and calcitonin receptor (CTR) and compare cagrilintide interactions and the dynamics of receptor complexes with previously reported structures of receptors bound to rat amylin, salmon calcitonin or recently developed amylin-based peptides