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Based on preclinical (animal and cellular) data only, inhibition of NNMT by 5-Amino-1MQ is theorised to: Raise intracellular NAD+ levels Activate SIRT1 and other sirtuins (proteins linked to metabolic regulation) Reduce fat cell (adipocyte) size and proliferation Improve insulin sensitivity These effects have been demonstrated in mouse models (Neelakantan et al., 2019), but robust human clinical trial data are currently absent

Weekly Dosing Schedule for the First Month After the first week, a weekly dosing schedule is used for the next month

That difference matters for expectations

Am J Gastroenterology

The use of ultrasound-guided injections in the study ensured precise delivery of the treatment into the small rabbit knee joint, improving the accuracy and consistency of the intervention