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Orforglipron represents a potential new therapeutic option for individuals with type 2 diabetes considering initiation of GLP-1 receptor agonist therapy who might prefer an alternative to the subcutaneous route of administration, Julio Rosenstock, MD, FACE, senior scientific advisor for Velocity Clinical Research, director of Velocitys site at Medical City Dallas and clinical professor of medicine at the University of Texas Southwestern Medical Center, and colleagues wrote

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For these patients, a GLP-1 that produces large rapid weight loss without a muscle preservation strategy is trading one metabolic problem for another