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MASH can lead to liver damage, liver cancer, and death if it gets worse over time
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This likely explains why dual GLP-1/GIP agonists, such as tirzepatide, continue to show dose dependent nausea, particularly during titration, despite modest improvements in tolerability compared with GLP-1 monotherapy (20)
Hypophosphatemia can lead to respiratory muscle impairment, failure to wean off mechanical ventilation, myocardial dysfunction, arrhythmias, and rhabdomyolysis
In clinical practice, these medications are generally not considered first-line treatment for PCOS
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