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For patients starting fresh, or switching from semaglutide for efficacy reasons, tirzepatide remains the more proven option at comparable weight loss levels without the dysesthesia risk

Further research can be focused on understanding GSHs potential role in restoring Th17 responses specific to HIV-associated GI complications and its impact on the development of IRIS if co-administered with antiretroviral agents

Harris CB, Chowanadisai W, Mishchuk DO, et al