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Other side effects that can occur include: Excessive sweat production Rapid weight gain Pain when breathing Shortness of breath when lying down Anxiety Increased or irregular heart rate Numbness, tingling or muscular weakness Increased thirst Urinary frequency B12 injections can also cause allergy symptoms immediately after administration, like difficulty breathing, a swollen throat, mouth, or swelling of the mouth, tongue or face

It is an investigational drug in clinical trials

[24] found that HFpEF patients exhibited more significant microcirculation involvement compared to those without HFpEF

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