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Needle size, for example, is exceedingly small, making subcutaneous administration at home relatively painless compared to larger needle gauges used with thicker medications for things like blood draws

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May 13 2020;18(1):47

In terms of the correlations between the severity of depression, as measured by CDI scores, and the studied metabolites at baseline, only the correlation of CDI with 5-HIAA was found to be significant (r=0.334, p=0.011, n=57)

Molloy AM, Daly S, Mills JL, Kirke PN, Whitehead AS, Ramsbottom D, Conley MR, Weir DG, and Scott JM (1997)