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The early program included PK studies in rats and mini pigs, as well as efficacy in db/db mice, to select derivatives that combined a long PK profile with high in vivo GLP-1R potency (53)

The main novelty of this drug is that it demonstrated in studies the most significant weight reduction among the drugs: 21 to 22.5% weight loss at its highest dose

Novo Nordisk has also asked European Union regulators to expand the use of the drug for heart problems

There are about 80,000 non fatal strokes and 605,000 first-time heart attacks in the US per year

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