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Upon nucleophilic attack of the phenolic oxygen atom at bromopropanol, the ligand was extended with an aliphatic terminal hydroxy group

| Target Concentration | BAC Water to Add | Dose per 10 units on syringe | |---------------------|-----------------|------------------------------| | 6mg/ml | 2.0ml | 0.6mg | | 12mg/ml | 1.0ml | 1.2mg | | 4mg/ml | 3.0ml | 0.4mg | **Best for:** Patients transitioning from 2mg to 4mg weekly doses

Etrolizumab for maintenance therapy in patients with moderately to severely active ulcerative colitis (LAUREL): a randomised, placebo-controlled, double-blind, phase 3 study

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Consequently, its known salutary effect on gastrointestinal lesions, its effect on chronic inflammation lesions such as adjuvant arthritis and its effect as a non-steroidal anti-inflammatory agent in NSAlAs-induced gastrointestinal lesions were simultaneously studied in rats