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GLP-1 Medications vs Traditional Weight Loss Drugs Older weight loss medications like phentermine, orlistat, or naltrexone-bupropion typically produce 5-10% weight loss compared to 15-22% with GLP-1 medications

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Misra, Comparative efficacy and safety of semaglutide 2.4 mg and tirzepatide 515 mg in obesity with or without type 2 diabetes: A systematic review of Phase 3 clinical trials

Diabetes Care (2010) 33:221724

Be aware of this and other potential side effects of alpha-lipoic aid use, which are discussed in the Concerns and Cautions section of our Alpha Lipoic Acid Review