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In this disease, the brain needs high energy levels and depends on mitochondrial function

Free Radic Biol Med 88:314336 Zhang J, Zhang R, Zhan Z, Li X, Zhou F, Xing A, Jiang C, Chen Y, An L (2017) Beneficial effects of sulforaphane treatment in Alzheimers disease may be mediated through reduced HDAC1/3 and increased P75NTR expression

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This matters because of the time scale