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The tirzepatide dosing schedule follows a different titration pattern than semaglutide, which means the timing of GI symptom onset and adaptation will differ even if you experience the same types of symptoms

Therefore, its unknown whether its necessary to cycle DSIP

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Front Neurol 14:1127878 Genchi A, Brambilla E, Sangalli F, Radaelli M, Bacigaluppi M, Furlan R, Andolfo A, Drago D, Magagnotti C, Scotti GM, Greco R, Vezzulli P, Ottoboni L, Bonopane M, Capilupo D, Ruffini F, Belotti D, Cabiati B, Cesana S, Matera G, Leocani L, Martinelli V, Moiola L, Vago L, Panina-Bordignon P, Falini A, Ciceri F, Uglietti A, Sormani MP, Comi G, Battaglia MA, Rocca MA, Storelli L, Pagani E, Gaipa G, Martino G (2023) Neural stem cell transplantation in patients with progressive multiple sclerosis: an open-label, phase 1 study