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doi: 10.1016/j.jep.2018.08.037 101 Al ShahraniMChandramoorthyHCAlshahraniMAbohassanMEidRARavichandranKet al

Contraindications and precautions Consider avoiding DSIP or consulting a physician if: Pregnant or breastfeeding (insufficient safety data) Taking naloxone or other opioid antagonists (may block effects) Using medications metabolized by peptidases (potential interactions) History of immune disorders (theoretical immunogenicity concern) Already using multiple sleep medications Drug interactions Because DSIP degrades via amino-peptidases in blood, medications affecting these enzymes (like the ACE inhibitor captopril) could theoretically alter DSIP metabolism

These reflect accelerated bone turnover, both resorption and formation activity

Standard Ascorbic Acid has a limitation: it is water-soluble, while our cell membranes are made of fat (lipids)

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