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The first seven trials involved patients with T2DM and baseline glycated hemoglobin levels ranging from 7.3 to 8.7, whereas the most recent SELECT trial focused on nondiabetic patients with overweight or obesity and preexisting cardiovascular disease

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Interestingly, after discontinuation, the Harmony Outcomes trial (2018) reported that albiglutide did significantly reduce cardiovascular events by ~22% versus placebo ( [8] )

Improves Tolerance Over Time: Studies have shown that when patients stick to a proper titration schedule, their bodies become more tolerant of semaglutide, and side effects like diarrhea may diminish

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