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Overall, no dose-dependent differences in TEAEs were observed

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Considering a high contribution of sulfation in acetaminophen metabolism, the importance of oxidation in APAP toxicity and of glutathione in APAP detoxification, more studies are needed to establish the relationship between polymorphisms in SULT , GST and CYP genes, and interindividual variability in response to acetaminophen

Folate deficiency is common in menstruating women, older adults, alcoholics, and those with gut issues or chronic health conditions