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It was also recently approved to reduce the risk of sustained kidney function decline in adults with type 2 diabetes and chronic kidney disease

10.1007/s40261-024-01351-5 77 KawachiY.FujishimaY.NishizawaH.TanakaA.YoshidaH.NiwanoS.et al (2025)

Contraindications JANUMET XR is contraindicated in patients with: Severe renal impairment (eGFR below 30 mL/min/1.73 m2) [see Warnings and Precautions (5.1)]

Furthermore, deletion of Sesn2 intensifies LPS-induced ferroptosis and impairs the ferroptosis and immunological response of DCs after cecal ligation and puncture (74)