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NMDA receptor modulation is consistent with DSIPs observed effects on cortical EEG activity, delta-wave induction, and neuroprotective properties in stroke and hypoxia models

Fish with high levels of mercury (tilefish from the Gulf of Mexico, shark, swordfish, and king mackerel) should be avoided

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People experiencing unexplained weight changes, severe gastrointestinal symptoms or possible endocrine conditions should obtain a complete medical evaluation

A biopsy should be considered when the pigmentation occurs in areas with a higher risk for melanoma, such as the maxillary gingiva or palate, especially if a clear link to the medication cannot be confirmed [12]