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This key effect of GSHee is connected to the findings that GSHee reduced the ability of fentanyl to lower pH, pO 2 and sO 2 while elevating pCO 2 (all consistent with a fall in Ve) and blunted the fentanyl-induced increase A-a-gradient (i.e., impaired gas-exchange in the lungs)

A major goal of these studies is to see how the benefits mentioned above stack up against risks like diabetic ketoacidosis, which may be a concern with this drug class in type 1 diabetes

Only those achieving at least a 5% reduction in body weight were eligible for randomization

These items can work in conjunction with each other