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In vivo studies in humans have shown that skeletal muscle insulin resistance fuels hepatic lipid accumulation by causing the diversion of substrates from ingested carbohydrates away from skeletal muscle glycogen synthesis toward hepatic DNL (102, 103)

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It can complement other therapies such as bronchodilators, corticosteroids, and antibiotics, potentially improving treatment outcomes and symptom management

Tirzepatide affects gastric emptying, which can alter the absorption of oral medications including insulin, sulfonylureas, oral contraceptives, and narrow therapeutic index drugs like warfarin