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Tonmyas active ingredient is cyclobenzaprine, a tricyclic drug that has been on the market for 50 years

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Neelakantan H, Vance V, Wetzel MD, Wang HY, McHardy SF, Finnerty CC, Hommel JD, Watowich SJ. Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse high-fat diet-induced obesity in mice. Biochem Pharmacol. 2018 Jul;154:161-171. doi: 10.1016/j.bcp.2018.05.003. Epub 2018 May 5. PMID: 29738706; PMCID: PMC6015571

Semaglutide, on the other hand, is a GLP-1 receptor agonist originally designed to manage type 2 diabetes