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For example, in ice age animals, the content of certain hydrophobic amino acids (such as leucine, isoleucine, valine, etc.) is relatively high, while the content of hydrophilic amino acids (such as serine, threonine, asparagine, etc.) is relatively low

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lncRNAs or miRNAs could be manipulated by small interfering RNAs, antisense RNAs, RNA mimics, or CRISPR/Cas9 carried by nanoparticle-based delivery systems