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Diagnosis requires colonoscopy with mucosal biopsies demonstrating characteristic histologic features: continuous inflammation limited to the mucosa and submucosa, crypt architectural distortion, and increased inflammatory cells

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This is also the period where metabolic markers start improving measurably

10.1016/j.phanu.2023.100352 441 TangG.PiL.GuoH.HuZ.ZhouC.HuQ.et al (2022)