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Whereas it is unlikely that the topical preparation as such immediately and directly reaches the hair bulb region, it has been shown that drug delivery to the skin occurs also through the hair follicles [32]

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5.4 Molecular genetic alterations Characteristic inactivating mutations of the PRKAR1A gene (17q24.2) are immunohistochemically confirmed by the loss of expression of the PRKAR1A marker [47]

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Testicular Tissue Extraction The rat testicular tissues were stripped, and the general pathological changes in the testicular tissue were observed