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found that acetaminophen exposure to rats resulted in a concentration-related increase in CYP2E1 in rat brains

[DOI] [PMC free article] [PubMed] [Google Scholar] 19.Vargas-Uricoechea H., Nogueira J.P., Pinzn-Fernndez M.V., Schwarzstein D

As already mentioned, Ero1 activity might lead indirectly to the production of GSSG, as will any reduction of ER oxidoreductases by GSH

They proposed that the absence of a mechanism to restore alterations in methylation/demethylation pattern after an environmental insult could result in an accumulation of 5mC and 5hmC during the course of AD [135]