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accordingly, the absence of a stable teratogenic pattern should not be interpreted as proof of safety ( From a practical standpoint, the most defensible position remains planned exposure avoidance: explicit fertility planning, reliable contraception during treatment, label-informed discontinuation before conception attempts, immediate cessation once pregnancy is recognized, and active metabolic maintenance during the washout period to reduce rebound-related gestational risk ( 4.5.1 Post-discontinuation weight rebound and gestational risk Evidence for post-discontinuation weight rebound and related gestational risk is derived predominantly from non-PCOS or mixed-population cohorts rather than from PCOS-specific longitudinal studies

In June 2024, the company announced a new $4.1 billion manufacturing site in Clayton, North Carolina, on a 56-acre campus ( [5] )

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This common plateau occurs when weight loss abruptly slows down or stops completely, leading patients to mistakenly believe the medication is no longer effective anymore

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