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EMBO Mol Med 16 , 12841309 (2024)
Why Preclinical Results Cannot Resolve the Salt Question Animal studies may investigate BPC-157 under a particular formulation, but they do not establish that every commercial salt form has the same: Purity Stability Absorption Impurity profile Pharmacokinetics Safety A salt-form claim must therefore be supported by evidence concerning that exact material rather than by BPC-157 literature in general
To further mitigate risk, many studies involve sentinel subjects typically only 1 participant on the active drug and 1 on placebo who receives the investigational drug before the remaining participants in the cohort are dosed
Roscilli G, Marra E, Mori F, Di Napoli A, Mancini R, Serlupi-Crescenzi O, et al