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Aldehyde dehydrogenase inhibition combined with phenformin treatment reversed NSCLC through ATP depletion

GLP-1RAs: glucagon-like peptide-1 receptor agonists, BCAA: branched chain amino acids, mTOR: mammalian target of rapamycin, DXA: dual-energy X-ray absorptiometry, BIA: bioimpedance analysis Novel pharmacological approaches Besides behavioral strategies, emerging pharmacologic agents, comprising anabolic and anti-catabolic drugs, have been demonstrated to be effective in the prevention and treatment of sarcopenia or disproportionate lean mass loss in patients receiving GLP-1RAs

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Hyperthyroidism induced a substantial increase in serum CK and LDH activities compared to the control values