Pay in 4 interest-free payments of $5.72 Learn more
Ships within 48 hours · Estimated delivery Aug 25 - Aug 30
certificate of analysis available on request Research Applications Suitable Laboratory Uses for 5-Amino-1MQ NNMT enzyme inhibition assays IC50 determination, target engagement confirmation, and 1-MNA quantification NAD+ salvage pathway modulation studies nicotinamide flux, NMN and NAD+ pool measurement SAM/SAH methyl-donor pathway and epigenetic methylation capacity research Adipocyte biology lipogenesis, adipocyte differentiation, fat mass, and lipid storage pathway studies SIRT1 and SIRT3 activation and insulin sensitivity pathway investigations Mitochondrial function and energy expenditure pathway research Skeletal muscle physiology muscle function, sarcopenia pathway, and mitophagy-related studies NNMT-overexpressing cancer cell line studies anti-proliferative and apoptotic pathway research Gut microbiome modulation research in diet-induced obesity models Cardiovascular metabolic pathway studies homocysteine, NF-B, STAT3, redox signalling Comparative NNMT inhibitor research 5-Amino-1MQ vs
The eluted fractions were combined, concentrated by distillation under reduced pressure, and recrystallized from small amounts of anhydrous ethanol and acetone to afford 4.15 g (yield: 43 %) of L-carnitine
For this, a mechanism-based PK-PD in silico model was first developed to inform on an appropriate human GLP-1R potency
Dixneuf, A
2025;105(3):e213916
