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Important safety information: GLP-1 medications carry an FDA boxed warning about thyroid C-cell tumors seen in animal studies and are contraindicated with a personal or family history of medullary thyroid carcinoma (MTC) or MEN2

While the employed rodent model replicates key metabolic and histopathological features of the human condition, and the conservation of the identified target pathways between species supports the biological plausibility of our findings, several critical aspects remain to be fully addressed

doi:10.1111/odi.12446

The subsequent rise in intracellular calcium levels and the possible activation of PKC are thought to result in the exocytosis of vesicles filled with growth hormones from these pituitary cells

Control (Cont.) group: Rats had free access to standard laboratory diet and water