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Therefore, recommending strategies to mitigate BIPN without interfering with the antitumor mechanism of BTZ remains challenging

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Varying concentrations of clotrimazole added to the cultured keratinocytes resulted in a dose dependent inhibition of the activities of the microsomal cytochrome p450 dependent monooxygenases aryl hydrocarbon hydroxylase and 7-ethoxycoumarin O-deethylase

Oxidative stress induced by paracetamol overdose is mainly attributed to mitochondrial superoxide and peroxynitrite[24]