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If you have low levels of vitamin B12 or suffer from depression of unknown cause, a Vitamin B12 IV procedure may be the treatment you need

The general principle is straightforward

Yildiz et al., 2000

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Pooling across the field, a 2025 meta-analysis of seven randomized controlled trials, covering 456 participants, reported a standardized mean difference of -0.72 for wrinkle reduction, though the analysis noted high heterogeneity between studies and that roughly 40% of trials had industry funding both factors that warrant caution in interpreting the pooled effect size