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This creates a counterintuitive incentive: a PBM maximizes rebate revenue by favoring high-list-price drugs, since rebates are typically calculated as a percentage of list price

For patients where heart disease is the primary concern alongside weight, the cardiovascular trial evidence behind Wegovy is currently more developed

Blood Tests That May Be Affected by Semaglutide Glucose and HbA1c respond predictably as blood sugar control improves, so lower fasting glucose or a fall in A1c usually reflects therapeutic effect rather than assay interference

The HR for the expanded MACE outcome was similar to that of the primary outcome (HR 0.82

After 8 weeks of treatment, tirzepatide significantly reduced fasting plasma glucose levels, HbA1c levels (a measure of long-term blood sugar control), and body weight compared to the placebo