Generic orforglipron, when it eventually becomes available, could see pricing discounts of 80-90% below brand, following the pattern seen with other generic small molecules
L-Carnitine is an endogenous substance involved in energy metabolism
A scientist named Hansely developed the stress adaptation theory, which found that stressed animals had enlarged adrenals, destroyed gastric lining, and shrunk thymus gland and lymphatics, and this led to the idea that there must be a cytoprotective or organoprotective compound in the gut 4m6s
But usually, we have a decent idea of whats working and whats not. The mechanistic logic for gut effects has a known route
Indeed, obese patients were enrolled (mean BMI: 29.2 5.3 kg/m 2 in the SGLT2i-preceding group and 29.4 5.5 kg/m 2 in the GLP1Ra-preceding group) in this study, and the influence of combination therapy on obesity-related glomerulopathy was not evaluated sufficiently