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Long-term metformin use clearly associates with increased b12 deficiency rates

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The FDA permits compounding when patients cannot access FDA-approved alternatives due to allergies to inactive ingredients, need for a different dosage form (such as liquid instead of pills), or medication shortages

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A 2024 randomized controlled trial (RCT) with 60 women (ages 40-65) applied 0.1% GHK-Cu cream twice daily for 12 weeks, yielding 31% wrinkle reduction (visia analysis) and 28% improved skin elasticity versus placebo (Kim et al., 2024)