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This hormone may activate the ghrelin receptors in the pituitary gland, also known as the Growth Hormone Secretagogue receptors (GHS-R1a) which may trigger the release of growth hormone
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GHRP-2 has also been studied for its ability to stimulate GH in patients with mutated GHRH receptors demonstrating that GHSR-1a provides an independent rescue pathway for GH release even when the GHRH axis is compromised (Maheshwari et al., 2002)
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